Differences Between B-Cells and T-Cells

 

Although mature lymphocytes all look pretty much alike, they are extraordinarily diverse in their functions. The most abundant lymphocytes are:

B lymphocytes (often simply called B cells) and
T lymphocytes (likewise called T cells).

Some of the differences between B Cells and T Cells are as follows:

S.N.	Properties	B-Cells	T-Cells
1	Name	B lymphocytes	T lymphocytes
2	Origin	Bone Marrow	Thymus
3	Position	Outside Lymph Node	Interior of Lymph Node
4	Membrane receptor	BCR (= immunoglobulin) for antigen	TCR for antigen
5	Connections	B-cells can connect to antigens right on the surface of the invading virus or bacteria.	T-cells can only connect to virus antigens on the outside of infected cells.
6	Tissue Distribution	Germinal centres of lymph nodes, spleen, gut, respiratory tract; also subcapsular and medullary cords of lymph nodes	Parafollicular areas of cortex in nodes, periarteriolar in spleen
7	Life Span	Life span is short	Life span is long
8	Surface Antibodies	Surface Antibodies present	Absence of surface antibodies
9	Secretion	They secrete antibodies	They secrete Lymphokines
10	Function	В-cells form humoral or antibody-mediated immune system (AMI).	T-cells form cell-mediated immune system (CMI).
11	Blood	20% of lymphocytes	80% of lymphocytes; CD4 > CD8
12	Formation	They form plasma cells and memory cells.	They form killer, helper and suppressor cells.
13	Movement to Infection Site	Plasma cells do not move to the site of infection.	Lymphoblasts move to the site of infection.
14	Function	Plasma cells do not react against transplants and cancer cells.	Killer cells react against transplants and cancer cells.
15	Function	Plasma cells have no inhibitory effect on immune system.	Suppressor cells inhibit immune system.
16	Function	They defend against viruses and bacteria that enter the blood and lymph.	They defend against pathogens including protists and fungi that enter the cells.